Serious - Use Alternative (1)phenytoin will decrease the level or effect of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Isosorbide dinitrate and isosorbide mononitrate are mainly excreted in the urine. This information is not individual medical advice and does not substitute for the advice of your health care professional. May repeat in 5 minutes if needed. [9]. Your dose may need to be gradually decreased.Although unlikely, when this medication is used for a long time, it may not work as well and may require different dosing. Modify Therapy/Monitor Closely. Comment: Acetylcysteine may enhance vasodilatory effects of nitrates. Dosage form: tablet, extended release Advise patients of the likelihood of headache, particularly with initial nitrate therapy. %
This dose should be increased to 10 mg by the second or third day of therapy. Do not break the 30 mg tablet. After . Importance of instructing patients receiving isosorbide dinitrate for relief of acute attacks of angina pectoris to consult a clinician or go to a hospital emergency room immediately if chest pain is not relieved after 3 doses approximately every 5 minutes, because inability to relieve chest pain may indicate acute MI. affecting hepatic/intestinal enzyme CYP3A4 metabolism. Properly discard this product when it is expired or no longer needed. Risk of increased SBP, angina pectoris. Tell your pharmacist what products you are using, and ask how to use them safely (especially cough-and-cold products, diet aids, or NSAIDs such as ibuprofen/naproxen).Isosorbide mononitrate is very similar to isosorbide dinitrate. Modify Therapy/Monitor Closely. Do not start, stop, or change the dosage of any medicines without your doctor's approval.Some products that may interact with this drug include: drugs to treat erectile dysfunction-ED or pulmonary hypertension (such as sildenafil, tadalafil), riociguat, vericiguat.Some products have ingredients that could worsen your heart failure. The recommended starting dose of IMDUR Tablets is 30 mg (given as a single 30 mg tablet or as 1/2 of a 60 mg tablet) or 60 mg (given as a single tablet) once daily. Copyright(c) 2023 First Databank, Inc. Mechanism: additive vasodilation. Avoid long-acting dosage forms in the early management of acute MI or heart failure since the effects are difficult to terminate rapidly should excessive hypotension or tachycardia occur. Minor/Significance Unknown. Avoid or Use Alternate Drug. Monitor Closely (1)tecovirimat will decrease the level or effect of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Why Use Isosorbide Dinitrate vs Isosorbide Mononitrate? duvelisib will increase the level or effect of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Isosorbide mononitrate (ismo , monoket ), Isosorbide mononitrate (Ismo , Monoket ), HONcode standard for trust- worthy health, Pediatric Oncology: Diagnosis And Prognosis Communication, Works by relaxation of smooth muscle, producing a vasodilator effect on the peripheral veins and arteries with more prominent effects on the veins. Consult your doctor before breast-feeding. 2 0 obj 2 0 obj
May induce methemoglobinemia. Avoid or Use Alternate Drug. Tell your doctor all medications and supplements you use. It is recommended that minoxidil be taken with a diuretic and beta blocker (see minoxidil side effects) May take without regard to food Hair loss (off-label) Dosing: 0.25 - 5 mg once daily See low-dose oral minoxidil for hair loss May take without regard to food Kidney disease Minoxidil can exacerbate fluid retention in kidney disease. Supplied: Regular release tablets: 10 mg, 20 mg. Extended release tablets: 30 mg, 60 mg, 120 mg. CLINICAL PHARMACOLOGY The principal pharmacological action of nitroglycerin is relaxation of vascular smooth muscle and consequent dilatation of peripheral arteries and veins, especially the latter. Either increases effects of the other by pharmacodynamic synergism. Increased risk of orthostatic hypotension. Use Caution/Monitor. The daily dose of IMDUR Tablets should be taken in the morning on arising. Coadministration of apalutamide, a strong CYP3A4 inducer, with drugs that are CYP3A4 substrates can result in lower exposure to these medications. and formulary information changes. We comply with the HONcode standard for trustworthy health information. It is an anti-anginal agent that works by relaxing the smooth muscles of both arteries and veins, but but predominantly veins to reduce cardiac preload. Coadministration of apalutamide, a strong CYP3A4 inducer, with drugs that are CYP3A4 substrates can result in lower exposure to these medications. informational and educational purposes only. Typically applied to chest. Use Caution/Monitor. Copyright 2021 GlobalRPH - Web Development by. Avoid or Use Alternate Drug. If coadministration is unavoidable, monitor patients for loss of therapeutic effect of these drugs. Consult your doctor before breastfeeding. Serious - Use Alternative (1)abametapir will increase the level or effect of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Mitotane is a strong inducer of cytochrome P-4503A4; monitor when coadministered with CYP3A4 substrates for possible dosage adjustments. fosphenytoin will decrease the level or effect of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. commonly, these are generic drugs. Use Caution/Monitor. Isosorbide mononitrate conventional tablets, peak: 0.51 hour. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Below is a conversion table to enable using this preparation in place of standard release isosorbide mononitrate and modified release (M/R) preparations which are not going to be kept. ~}xp%0Vg^r3WT_a-~qvQD]dvo{,Z@${ssJC j(2GW`_? Use Caution/Monitor. Headache, the most frequent adverse effect, may be severe (persistent or transient) and is perceived as a pulsating, throbbing sensation; frequent early in therapy, usually diminishes rapidly, and may disappear within several days to weeks of continuous therapy. Contraindicated. SIDE EFFECTS: Headache, dizziness, lightheadedness, nausea, and flushing may occur as your body adjusts to this medication. Lencapavir may increase CYP3A4 substrates initiated within 9 months after last SC dose of lenacapavir, which may increase potential risk of adverse reactions of CYP3A4 substrates. Imdur and Ranexa belong to different drug classes. Imdur 60 mg od Imdur 120 mg od REFERENCES 1. isosorbide mononitrate increases effects of ergotamine by decreasing metabolism. Use Caution/Monitor. Minor (1)acetazolamide will increase the level or effect of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Any missing drug warnings or information does not in any way guarantee the safety, effectiveness, or the lack of adverse effects of any drug. Prophylactic management in situations likely to provoke angina attacks in patients who fail to respond to sublingual nitroglycerin: 2.55 mg of isosorbide dinitrate should be placed under the tongue approximately 15 minutes prior to engaging in such activities. HOW TO USE: Take this medication by mouth as directed by your doctor, usually twice a day. Titrate dosages to levels similar to those recommended for the fixed-combination preparation and administer both drugs at least 3 times daily. Observe for possible additive hypotensive effects during concomitant use. IMDUR, generics Dosage Forms 100 mg/250 mL premixed bottle - UHN Note: 0.84 mL alcohol per 100 mL solution 100 mcg/mL 200 mcg/mL 400 mcg/mL 10 mg/10 mL . The patient should be sitting immediately after sublingual or intrabuccal administration. Serious - Use Alternative (1)isosorbide mononitrate increases effects of ergoloid mesylates by decreasing metabolism. The dose could be doubled, and even doubled again, in patients tolerating this dose but failing to respond to it. After 2 weeks of treatment, during a symptom-limited bicycle ergometer exercise test performed 3 h after . Use Caution/Monitor. Your doctor may recommend treating headaches with an over-the-counter pain reliever (such as acetaminophen, aspirin). Monitor Closely (1)bosentan will decrease the level or effect of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. isosorbide mononitrate, sildenafil. Safety and effectiveness of Isordil in pediatric patients have not been established. 1 - 2 sprays on or under the tongue at the onset of pain. Use Caution/Monitor. Serious - Use Alternative (1)voxelotor will increase the level or effect of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated (1)isosorbide mononitrate, avanafil. Contraindicated (1)isosorbide mononitrate, sildenafil. tazemetostat will decrease the level or effect of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Imdur (isosorbide mononitrate) Extended Release and Nitrolingual Pumpspray (nitroglycerin lingual spray) are vasodilators indicated for the prevention of angina pectoris. Many people using this medication do not have serious side effects.Tell your doctor right away if you have any serious side effects, including: fainting, fast/irregular/pounding heartbeat.A very serious allergic reaction to this drug is rare. Hydralazine undergoes extensive liver metabolism. Stiripentol is a CYP3A4 inhibitor and inducer. Crofelemer has the potential to inhibit CYP3A4 at concentrations expected in the gut; unlikely to inhibit systemically because minimally absorbed. Imdur Tablets, for oral administration, contain either 30 mg, 60 mg or 120 mg of isosorbide mononitrate in an extended-release formulation. Tell your doctor if this medication stops working well (for example, you have more frequent or worsening chest pain). Monitor Closely (1)isosorbide mononitrate, bretylium. Warn all patients receiving organic nitrates or nitrites about the potential interaction between the drugs and selective PDE inhibitors, even if they currently are not receiving the drugs, since there is substantial potential for patients to receive the drugs from another clinician, from a friend, with little or no clinical intervention (e.g., via the Internet), or illicitly. Use caution. Potentially fatal hypotension. Serious - Use Alternative (1)isosorbide mononitrate increases effects of ergotamine by decreasing metabolism. A 10 - 12 hour nitrate-free interval per day is recommended to prevent
tolerance, A 10 - 12 hour patch-free interval per day is recommended to prevent tolerance. Compare formulary status to other drugs in the same class. Clinicians unfamiliar with their patients drug history, especially those involved in emergency care (e.g., for presumed myocardial infarction or ischemia), should take a careful history so that concomitant use of organic nitrates or nitrites with selective PDE inhibitors can be avoided. Use Caution/Monitor. Take the first dose in the morning right after you . iloperidone increases levels of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Either increases effects of the other by pharmacodynamic synergism. Serious - Use Alternative (1)isosorbide mononitrate increases effects of cabergoline by decreasing metabolism. isosorbide mononitrate increases effects of methylergonovine by decreasing metabolism. May increase dosage to 120 mg (as a single 120-mg tablet or as two 60-mg tablets) once daily after several days; 240-mg dosages rarely needed. Isosorbide dinitrate has been used effectively for diffuse esophageal spasm [off-label] without gastroesophageal reflux to relieve pain, dysphagia, and spasm. For information about enrolling in MedicAlert, call 1-888-633-4298 (US) or 1-800-668-1507 (Canada). Serious - Use Alternative (1)fosphenytoin will decrease the level or effect of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Importance of clinicians unfamiliar with their patients drug history, especially those involved in emergency care (e.g., for presumed myocardial infarction or ischemia), to take a careful history so that concomitant use with selective PDE inhibitors can be avoided. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. 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