Epub 2020 May 23. However, if performed, abnormal vaginal screening test results should be managed according to published recommendations (BII).Perkins RB, Guido RS, Castle PE, et al. endstream endobj startxref Available at: Updated Guidelines for Management of Cervical Cancer Screening Abnormalities, https://journals.lww.com/jlgtd/Fulltext/2020/04000/2019_ASCCP_Risk_Based_Management_Consensus.3.aspx, https://journals.lww.com/jlgtd/pages/collectiondetails.aspx?TopicalCollectionId=2, https://www.asccp.org/management-guidelines, Alliance for Innovation on Women's Health, Postpartum Contraceptive Access Initiative, Expedited treatment or colposcopy acceptable*, Return to routine screening at 5-year intervals. In addition, the guidelines now recommend consideration of a patients screening history, along with current test results, to guide clinical decision making. breakthrough, but the recommendations retained a continued reliance on complicated algorithms and insufficiently appropriate ASCCP management guidelines for women with abnormal screening tests. 104 0 obj <> endobj Clinical judgment should always be used when applying a guideline to an individual patient because it is impossible ASCCP endorses the United States Preventative Services Task Force (USPSTF) cervical cancer screening guidelines. cotesting at intervals <5 years, or cytology alone at intervals <3 years. Przybylski M, Pruski D, Millert-Kaliska S, Krzyaniak M, de Mezer M, Frydrychowicz M, Jach R, urawski J. Biomedicines. The ASCCP Risk-Based Management Consensus Guidelines represent a consensus of nearly 20 professional organizations 2f8 Hf8*@r9MXNw6JXbc```3=20(.bbc`Sb0 Z Routine screening applies Smoking and alcohol cessation should be recommended to reduce the risk of HPV persistence and the development of HPV-related malignancies. J Low Genit Tract Dis. 117 0 obj <>/Filter/FlateDecode/ID[<2A3A72E8287AD77BE571CDCCA6D1568C><7C4167790C383844A9780EF022A9F20A>]/Index[104 29]/Info 103 0 R/Length 73/Prev 24323/Root 105 0 R/Size 133/Type/XRef/W[1 2 1]>>stream Finally, both clinicians and patients need to recognize that while most cases of cervical cancer can be prevented opinion. This information is designed as an educational resource to aid clinicians in providing obstetric and gynecologic care, and use of this information is voluntary. endstream endobj startxref Transformation Zone (LLETZ), and cold knife conization. c5K44s The 2019 ASCCP Risk-Based Management Consensus Guidelines1 represent a paradigm shift from using primarily results-based algorithms to using risk-based management based on a combination of current screening test results and past screening history. Screening recommended every 3 years for women 21-29. of a positive screening test to inform the next steps in management. Cervical Cancer Screening Department of Clinical Effectiveness V8 Approved by the Executive Committee of the Medical Staff on 06/15/2021 Screening not recommended AGE TO BEGIN Under 21 years of age SCREENING 21 - 29 years of age Liquid-based Pap test every 3 . Definitions tab - Definitions of terms in the app, a summary of the changes in the current guidelines from prior guidelines, and frequently asked questions. The guidelines effort received support from ASCCP and the National Cancer Institute. 2020 Oct;24(4):425. doi: 10.1097/LGT.0000000000000561. Class 2A carcinogen (i.e., HPV types 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, and 68). cotesting with HPV testing and cervical cytology, and cervical cytology alone. Dr. Castle has received HPV tests and assays at a reduced or no cost from Roche, Becton Dickinson, Arbor Vita Corporation, and Cepheid for research. Journal of Lower Genital Tract Disease25(4):330-331, October 2021. It is not intended to substitute for the independent professional judgment of the treating clinician. cytology in this document. Am J Obstet Gynecol 2007;197:34655. | Terms and Conditions of Use. The ASCCP Management Guidelines applications were developed by ASCCP. Federal government websites often end in .gov or .mil. Cytology every . Disclosure of Financial Support: The guidelines effort received support from the National Cancer Institute and ASCCP. recommendation revisions, minimizing the time needed to implement changes that are beneficial to patient care. endobj marked Pap smear, repeat colposcopy MAY not change management even if negative, so it may be appropriate to proceed with a diagnostic excisional procedure if review of material is not an option. 18 individual patient based on their current results and past history. How are these guidelines different? The new consensus guidelines are an update of the 2012 ASCCP management guidelines and were developed with input from 19 stakeholder organizations, including ACOG, to provide recommendations for the care of patients with abnormal cervical cancer screening results. Furthermore, since prior test results affect risk, patients with prior abnormalities often require surveillance with Table 1. 17-19 Patients with a history of abnormal test results require more frequent testing as recommended by the ASCCP. Specifically, the 2012 guidelines recommend colposcopy for all cytology results of low grade squamous intraepithelial lesion (LSIL) or higher for individuals aged 25 and above. 3. or call toll-free from U.S.: (800) 762-2264 or (240) 547-2156 long-term utility of the guidelines. MeSH M.H.E. The recommendation is more than a cytology or HPV follow up. For more information, please refer to our Privacy Policy. 6) The last screen shows the guidelines information for this patient. Copyright 2021 by the American Academy of Family Physicians. References to the published guideline information is also shown. hbbd```b``y"H|6*``v;dVNN\`z 5ByX|&X%^f X},;H8d5 w The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). 0 Children and young adults age 13 through 26 who have not been vaccinated, or who haven't completed the vaccine series, should get the vaccine as soon as possible. Among patients who have undergone hysterectomy but either have no previous diagnosis of CIN 2+ within the previous 25 years or have completed the 25 year surveillance period, screening is generally not recommended. Kruse GR, Lykken JM, Kim EJ, Haas JS, Higashi RT, Atlas SJ, McCarthy AM, Tiro JA, Silver MI, Skinner CS, Kamineni A. JNCI Cancer Spectr. 1 0 obj Copyright, 2002, 2006, 2013, 2019, 2020, 2021 ASCCP. endstream endobj 1177 0 obj <. The new consensus guidelines are an update of the 2012 ASCCP management guidelines and were developed with input from 19 stakeholder organizations, including ACOG, to provide recommendations for the care of patients with abnormal cervical cancer screening results. By using the app, you agree to the Terms of Use and Privacy Policy. HPV is spread by direct skin-to-skin contact and has tropisms for cutaneous or mucosal epithelial cells.1 A small subset of HPV types can cause cutaneous warts.2 The approximately 40 types that infect mucosal surfaces are typically spread through sexual contact, including vaginal, anal, or oral sex, and can be divided into low-risk and high-risk types based on their associated cancer risk. these guidelines. J Low Genit Tract Dis. HPV vaccination is not routinely recommended in individuals 27 years or older. Uterus: A muscular organ in the female pelvis. )CQq]/iGxJh HxLEc&tfAx%%NEz"ZCHQ($ 33_ Histopathological follow-ups within six months were also reviewed for correlation. Finally, both clinicians and patients need to recognize that while most cases of cervical cancer can be prevented Risk factors for HPV infection include early sexual contact, having multiple sex partners, a history of other sexually transmitted infections, HIV infection, an immunocompromised state, and not using barrier protection during sex.3,13,14, Persistent oral and genital HPV infections are associated with alcohol use and smoking.15,16 There is some evidence that human leukocyte antigen type may impact an individual's ability to clear HPV viruses.17 Although several factors have been associated with an increased risk of progression to cervical disease (e.g., age, body mass index, income, oral contraceptive use, race/ethnicity, smoking), persistent high-risk HPV infection is the most significant risk factor for progression.18,19, Infection with a low-risk HPV type does not preclude infection with a concomitant high-risk type. 2019 ASCCP Risk-Based Management Consensus Guidelines for Abnormal Cervical Cancer Screening Tests and Cancer Precursors J Low Genit Tract Dis . Guidelines cannot cover all clinical situations and clinical judgment is advised, especially in those circumstances which are not covered by the 2019 guidelines.Perkins RB, Guido RS, Castle PE, et al. In patients 30 to 65 years of age, cervical cancer screening should be performed every three years using cervical cytology alone, every five years using high-risk HPV testing alone, or every five years using cotesting. Obstet Gynecol 2013;121:82946. Following shared decision-making, however, it can be considered between 27 and 45 years of age in those who have not been previously vaccinated. Perkins, Rebecca B. MD, MSc1; Guido, Richard S. MD2; Castle, Philip E. PhD3; Chelmow, David MD4; Einstein, Mark H. MD, MS5; Garcia, Francisco MD, MPH6; Huh, Warner K. MD7; Kim, Jane J. PhD, MD8; Moscicki, Anna-Barbara MD9; Nayar, Ritu MD10; Saraiya, Mona MD, MPH11; Sawaya, George F. MD12; Wentzensen, Nicolas MD, PhD, MS13; Schiffman, Mark MD, MPH14; for the 2019 ASCCP Risk-Based Management Consensus Guidelines Committee, From 1Boston University School of Medicine/Boston Medical Center, Boston, MA, 2University of Pittsburgh/Magee-Women's Hospital, Pittsburgh, PA, 3Albert Einstein College of Medicine, New York, NY, 4Virginia Commonwealth University School of Medicine, Richmond, VA, 5Rutgers, New Jersey Medical School, Newark, NJ, 6Pima County Health & Community Services, Tucson, AZ, 8Harvard T.H. In 2019, the ASCCP updated consensus guidelines for the management of screening abnormalities, which are available as an open-access document on the Journal of Lower Genital Tract Disease website. Box 1. <> We don't have any prior history in this particular case. (Monday through Friday, 8:30 a.m. to 5 p.m. Available at: Risk estimate tables supporting the 2019 ASCCP risk-based management consensus guidelines. Management of results during post colposcopy surveillance (within past 7 years): Management of current HPV and/or cytology results for patients who previously were triaged to 1-year, 3-year or 5-year follow-up after colposcopy. found when histology or cytology is inconclusive such as a result of LSIL cannot rule out HSIL. <>/ExtGState<>/ProcSet[/PDF/Text/ImageB/ImageC/ImageI] >>/Annots[ 16 0 R 17 0 R] /MediaBox[ 0 0 612 792] /Contents 4 0 R/Group<>/Tabs/S/StructParents 0>> Long-term surveillance after treatment for histologic HSIL (CIN 2 or CIN 3) or AIS involves HPV-based testing at 3-year intervals for 25 years, regardless of whether the patient has had a hysterectomy either for treatment or at any point during the surveillance period (CIII). Updated guidelines were needed to incorporate these changes. In individuals immunized between 15 and 26 years of age and in individuals of any age who are immunocompromised, a three-dose series is recommended. Schiffman, Wentzensen: The National Cancer Institute (incl. Low-risk types cause warts, whereas the 15 high-risk types cause cervical intraepithelial neoplasia (CIN) and squamous cell carcinomas of the anogenital tract and oropharyngeal mucosa.3,4 Vertical or horizontal spread of HPV can occur during the perinatal period and is associated with oral infections and respiratory papillomatosis.5,6 Concomitant cervical and anal infections have been demonstrated in women without a history of anal intercourse and may be a result of autoinoculation.7. and N.W.) if 25yo Guideline IId. x][s~wj- 3JJ$*H>LA7C@&=v"`g3~.J~zw$N_%(r[Tii^V_tD$D+Aw8Ry]Q/>*_c{I3&TMZ{u6t7J35Il]~5H"j4jP^M$:^#:_kz]H,T AmR-h6/~p|`_M,6e%cDvE8+"KT =5A7Bed,V9W#O=26TE"MWfg(IGcU|H^i\G \%?&tU bWiS ]LPI-jb0> Saslow D, Solomon D, Lawson HW, Killackey M, Kulasingam SL, Cain JM, Garcia FA, Moriarty AT, Waxman AG, Wilbur DC, Wentzensen N, Downs LS Jr, Spitzer M, Moscicki AB, Franco EL, Stoler MH, Schiffman M, Castle PE, Myers ER, Chelmow D, Herzig A, Kim JJ, Kinney W, Herschel WL, Waldman J. J Low Genit Tract Dis. p8hr$`>$k:Qm"(YA0C`u`05LBVC24K(w0w0wt00T xE40C qvW@p `700C`0+fw004I7Xo28XK'3aw4a7.2t1lepa1k1n Cytology every three years (liquid or conventional) Recommend against annual Pap smear. Risk estimates supporting the 2019 ASCCP Risk-Based Management Consensus Provider beliefs in effectiveness and recommendations for primary HPV testing in3 health-care systems. In this case, management of routine screening results is the appropriate selection. Guidelines. of age and older. J Low Genit Tract Dis 2020;24:10231. Xiaojian Chen MS; Li Cheung PhD; Kim Choma, DNP; Megan Clarke, PhD; Christine Conageski, MD; Miriam Cremer, MD, MPH; After a diagnosis of high-grade histology or cytology, patients may undergo hysterectomy for reasons related or unrelated to their cervical abnormalities.If hysterectomy is performed for treatment, patients should have 3 consecutive annual HPV-based tests before entering long-term surveillance. CIN 3+ Risk Thresholds for Management. New abnormal screening test results after a negative HPV test within the previous 5 years indicate new, as opposed to persistent, HPV infection. through a program of screening and management of cervical precancer, no screening or treatment modality is 100% The ability to adjust to the rapidly emerging science is critical for the 2019 ASCCP risk-based management consensus guidelines for abnormal Please contact [emailprotected] with any questions. See permissionsforcopyrightquestions and/or permission requests. Egemen D, Cheung LC, Chen X, et al. ACS/ASCCP/ASCP guidelines 1. All 3 platforms show high . A Question to the 2019 ASCCP Risk-Based Management Consensus Guidelines. Schiffman M, Wentzensen N, Perkins RB, Guido RS. hb```o,g(v``X b n(f`$PpRME`%uA*?20FA@Z7a'(2 ^$ time. No industry funds were used in the development of ASCCP, 23219 Stringtown Rd, #210, Clarksburg, MD 20871. :RKA\U]57D~EGjU5=f8aiQ5\v8r*\|$;%/Se1}{W1G_I}%%[oa/UEwd\qrq^V>5^N^moO.J}].Jdw[ou+w\HY https://cervixca.nlm.nih.gov/RiskTables/ to maintaining your privacy and will not share your personal information without Confirm your email to receive complimentary access to the ASCCP Management Guidelines web application. Before This algorithm should not be used to treat pregnant women. 2019 ASCCP Risk-Based Management Consensus Guidelines Committee. Any updates to this document can be found on www.acog.orgor by calling the ACOG Resource Center. Bookshelf Routine Screening (within past 5 years): Management of HPV and/or cytology results obtained during routine cervical cancer screening and for patients where prior screening results did not result in colposcopy, but where risk was too high to return to routine screening. The Centers for Disease Control and Prevention reports that 79 million Americans are infected with HPV and an additional 14 million are newly infected each year.3 Data from early HPV vaccine trials suggest that the lifetime prevalence of the infection is 85% in women and 91% in men who have had at least one sex partner.8. Your message has been successfully sent to your colleague. the consensus process is available. Available at: ASCCP management guidelines app quick start guide. recommendations for the practice of colposcopy. -, Wright TC, Massad LS, Dunton CJ, et al. Follow-up after treatment: Management of current HPV and/or cytology results for patients who have previously been treated for dysplasia. What should we do to find out the next step for this patient? Women 30-65 and older who have had 3 consecutive negative Pap test and who have no history of CIN2 or 3, etc. 2019 ASCCP risk-based management consensus guidelines for abnormal cervical cancer screening tests and cancer precursors. Guidelines for Abnormal Cervical Cancer Screening Tests and Cancer Precursors (Perkins 2020) have been adopted. -, Egemen D, Cheung LC, Chen X, et al. All participating consensus organizations, including the Clinical judgment should always be used when applying a guideline to an individual patient because it is impossible Follow these Guidelines: If you are younger than 21You do not need screening. defined by IARC, including the 12 types that are considered Class 1 carcinogens, plus type 68 which is considered a Recommendations on New Standards of Colposcopy Practice, - Image Archive- EMR Templates- Patient Resources- Member Directory- Photo Gallery- Clinical Practice Listserv- Cases of the Month- Colposcopy Standards Paper Note- Vulvovaginal Disorders Resource. 2) Enter the patient's age and the clinical situation. Why were the guidelines revised now? prevalence of CIN3+ decreases due to HPV vaccination, and also as new screening and triage tests are introduced. Would you like email updates of new search results? management from one that is based on specific test results to one that is based on a patient's risk will allow for In addition, several new recommendations for 132 0 obj <>stream p16 and Other Epithelial Cancer Biomarkers. Sometimes cytology or pathology are not conclusive. 2 0 obj Who developed these guidelines? than in previous iterations of guidelines. Response to Letter to the Editor Regarding: 2019 ASCCP Risk-Based Management Consensus Guidelines for Abnormal Cervical Cancer Screening Tests and Cancer Precursors. -, Huh WK, Ault KA, Chelmow D, et al. and transmitted securely. This evaluation may include cervical cytology, colposcopy, diagnostic imaging, and cervical, endocervical, or endometrial biopsy. The management guidelines were revised now due to the availability of sufficient data from the United States showing Vaccination has been demonstrated to reduce the prevalence of vaccine-type HPV in females, anogenital warts, and precancerous cervical lesions. 2020 Oct;24(4):426. doi: 10.1097/LGT.0000000000000562. 8600 Rockville Pike The updated management guidelines aim to: Allow for a more complete and precise estimation of risk Provide more appropriate intervention for high-risk individuals (detect and treat more. 2 0 obj While the 2019 guidelines provide management recommendations for most results, certain situations do not have specific guidance. Should not be used to treat pregnant women are beneficial to patient care of., minimizing the time needed to implement changes that are beneficial to care... The clinical situation Letter to the 2019 ASCCP Risk-Based management Consensus guidelines of current and/or. 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Perkins RB, Guido RS and who have had 3 consecutive negative Pap test who... And cervical, endocervical, or cytology alone to our Privacy Policy to patient care and have... Had 3 consecutive negative Pap test and who have had 3 consecutive Pap! Wentzensen N, Perkins RB, Guido RS in.gov or.mil RB, Guido RS: guidelines! Monday through Friday, 8:30 a.m. to 5 p.m management Consensus guidelines have been adopted used to treat women... Cotesting at intervals < 3 years revisions, minimizing the time needed to implement changes that beneficial. ( Monday through Friday, 8:30 a.m. to 5 p.m have no history of CIN2 or 3,.! Be found on www.acog.orgor by calling the ACOG Resource Center, or endometrial biopsy negative Pap test who... App quick start guide for abnormal cervical Cancer screening tests and Cancer Precursors ( Perkins ). Disclosure of asccp pap guidelines algorithm 2021 support: the guidelines information for this patient tests and Cancer Precursors positive test. 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